Premier League champions Liverpool will face FA Cup holders Crystal Palace in the standout tie of the Carabao Cup fourth round.
Defending champions Newcastle United have been drawn against Tottenham Hotspur in another all-Premier League clash, while Arsenal—who last lifted the trophy in 1993—will host Brighton.
League Two side Grimsby Town, who stunned Manchester United in the previous round, continue their fairytale run with a home tie against Premier League outfit Brentford.
There is also historic interest in Wales, with three Welsh clubs reaching the last 16 for the first time. Wrexham will host Cardiff City in their first meeting since 2002, while Swansea City face a daunting trip to Manchester City.
Elsewhere, Wolves welcome Chelsea, and Wycombe Wanderers take on Fulham.
Full Carabao Cup Fourth-Round Draw
Arsenal v Brighton
Grimsby Town v Brentford
Swansea City v Manchester City
Newcastle United v Tottenham
Wrexham v Cardiff City
Liverpool v Crystal Palace
Wolves v Chelsea
Wycombe v Fulham
The fourth-round ties will be played in the week commencing 27 October.
